TESC

Across TCGA patient cohorts, TESC mutation is significantly associated with the RNA expression of many other genes, with 411 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TESC-associated genes across cancer lineages are EEF1E1-BLOC1S5, AP1B1P2, and DBIP2. Each is linked with TESC in more than 1 cancer types. Because this analysis shows association rather than direction, both TESC-to-partner and partner-to-TESC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EEF1E1-BLOC1S5 grouped by TESC-low versus TESC-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TESC→partner) and Y-score (partner→TESC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	EEF1E1-BLOC1S5 →	+0.082	+4.351	<.001	.002	3	2
UCEC	AP1B1P2 →	+0.143	+3.500	<.001	.002	3	2
COAD	DBIP2 →	+0.297	+4.415	.001	.006	3	2
LUSC	RNU7-197P →	+0.851	+7.924	<.001	.008	3	1
UCEC	PHF5A →	+0.433	+2.906	.008	.002	3	1
UCEC	TRMU →	+0.463	+3.491	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 411 associations by consensus.

EEF1E1-BLOC1S5 by TESC expression — SKCM

Explore this box plot interactively →