TESC

Across TCGA pan-cancer cohorts, TESC RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TESC’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TESC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TESC is over-expressed in tumor, although a few such as HNSC and KICH show the opposite, repressed pattern.

COAD, THCA, and LIHC are the cancer types where TESC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TESC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+4.498	<.001	12	view →
THCA	Female	II,III,IV	+2.846	<.001	11	view →
LIHC	Male	III,IV	+2.703	<.001	8	view →
LUAD	Male	All	+2.267	<.001	8	view →
HNSC	All	II,III,IV	−1.176	<.001	8	view →
READ	All	II,III,IV	+5.237	<.001	7	view →
KICH	Female	II,III,IV	−2.682	<.001	7	view →
BRCA	All	II,III,IV	−2.043	<.001	6	view →
LUSC	Female	All	−1.840	<.001	6	view →
CHOL	All	All	+6.247	<.001	5	view →
KIRC	Male	II,III,IV	−1.117	<.001	5	view →
STAD	All	All	+1.459	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TESC–COAD

Open the COAD breakdown →