TESC

Across TCGA patient cohorts, TESC mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TESC-associated genes across cancer lineages are Annexin-1, ATM, and MEK1. Each is linked with TESC in more than 1 cancer types. Because this analysis shows association rather than direction, both TESC-to-partner and partner-to-TESC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by TESC-low versus TESC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TESC→partner) and Y-score (partner→TESC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.570	+2.999	.020	.035	3	1
UCEC	ATM →	-0.569	-2.584	.007	.011	3	1
UCEC	MEK1 →	+0.577	+2.584	<.001	.011	1	1
UCEC	Notch1 →	+0.196	+2.584	.002	.011	1	1
UCEC	STAT3_pY705 →	-0.441	-2.584	<.001	.011	1	1
UCEC	Cyclin-B1 →	+0.583	+2.584	.025	.011	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Annexin-1 by TESC expression — UCEC

Explore this box plot interactively →