TESC

Across TCGA cell cohorts, TESC RNA expression is significantly associated with the go_rna of many other GO terms, with 4,252 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TESC-associated GO terms across cancer lineages are Regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway, Negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway, and Modification of postsynaptic structure. Each is linked with TESC in more than 10 cancer types. Because this analysis shows association rather than direction, both TESC-to-partner and partner-to-TESC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway grouped by TESC-low versus TESC-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TESC→partner) and Y-score (partner→TESC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway →	-0.185	-3.868	.001	<.001	3	11
STOMACH	Negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway →	-0.185	-3.868	.001	<.001	3	11
LUNG_NSCLC_LUSC	Modification of postsynaptic structure →	-0.128	-3.665	.007	<.001	3	8
OVARY	Positive regulation of calcium ion transport into cytosol →	-0.230	-1.875	<.001	.001	3	8
BONE	Positive regulation of sodium:proton antiporter activity →	-0.281	-1.277	<.001	.001	3	8
BONE	Substrate adhesion-dependent cell spreading →	-0.145	-0.892	<.001	.009	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,252 associations by consensus.

Regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway by TESC expression — STOMACH

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