TES

Across TCGA pan-cancer cohorts, TES mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TES data layer compared with 20 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TES mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TES expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

UCEC, LSCC, and CCRCC are the cancer types where TES mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.923	0.503	.006	14	view →
LSCC	DFS	Tertile	II,III,IV	0.589	0.889	.020	7	view →
CCRCC	OS	Tertile	II,III,IV	0.994	0.790	.041	3	view →
LUAD	DFS	Tertile	II,III,IV	0.664	0.273	.018	2	view →
GBM	OS	Quartile	All	0.349	0.634	.020	2	view →
PDAC	OS	Quartile	II,III,IV	0.280	0.527	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TES–UCEC (DFS)

Open the UCEC breakdown →