TES

Across TCGA pan-cancer cohorts, TES RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of TES’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TES RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TES is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

HNSC, KIRC, and KIRP are the cancer types where TES tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TES RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+1.259	<.001	12	view →
KIRC	Male	All	+0.778	<.001	9	view →
KIRP	All	IV	+2.274	<.001	8	view →
BLCA	Male	All	−1.442	.001	8	view →
THCA	All	All	−0.349	.001	7	view →
READ	All	All	−0.963	.005	5	view →
LIHC	All	All	+0.738	<.001	4	view →
CHOL	Male	All	+3.621	<.001	3	view →
BRCA	Female	All	−0.304	.010	3	view →
PRAD	All	All	−0.793	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

TES–HNSC

Open the HNSC breakdown →