TES

Across TCGA patient cohorts, TES mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TES-associated genes across cancer lineages are ASNS, EGFR, and eIF4E. Each is linked with TES in more than 1 cancer types. Because this analysis shows association rather than direction, both TES-to-partner and partner-to-TES results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by TES-low versus TES-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TES→partner) and Y-score (partner→TES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.456	+2.415	<.001	.003	3	2
UCEC	EGFR →	-0.153	-3.143	.006	.018	3	1
UCEC	eIF4E →	+0.150	+2.472	.044	.010	3	1
UCEC	eIF4G →	+0.262	+3.321	.017	.009	3	1
UCEC	FoxM1 →	+0.190	+1.362	.037	.037	3	1
UCEC	FOXO3a_pS318_S321 →	-0.127	-2.077	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

ASNS by TES expression — UCEC

Explore this box plot interactively →