TES

Across TCGA cell cohorts, TES mutation is significantly associated with the RNA expression of many other genes, with 73 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TES-associated genes across cancer lineages are C6orf118, PRDM2, and PDS5A. Each is linked with TES in more than 1 cancer types. Because this analysis shows association rather than direction, both TES-to-partner and partner-to-TES results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by TES-low versus TES-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TES→partner) and Y-score (partner→TES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.093	+2.378	<.001	.006	3	1
LARGE_INTESTINE	PRDM2 →	+0.569	+3.299	.009	.004	3	1
LARGE_INTESTINE	PDS5A →	+0.591	+3.212	.003	.006	3	1
LARGE_INTESTINE	NXF5 →	+0.019	+2.882	<.001	.001	3	1
LARGE_INTESTINE	LLGL1 →	+0.787	+3.067	.008	.009	3	1
LARGE_INTESTINE	TLR2 →	+1.015	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

C6orf118 by TES expression — LARGE_INTESTINE

Explore this box plot interactively →