TERT

Across TCGA patient cohorts, TERT RNA expression is significantly associated with the protein abundance of many other proteins, with 12,525 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TERT-associated proteins across cancer lineages are PRIM2, SSRP1, and SUPT16H. Each is linked with TERT in more than 5 cancer types. Because this analysis shows association rather than direction, both TERT-to-partner and partner-to-TERT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TERT versus PRIM2 in GBM, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TERT→partner) and Y-score (partner→TERT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRIM2 →	+0.522	+0.697	.001	.001	3	6
BRCA	SSRP1 →	+0.403	+0.415	<.001	.001	3	6
BRCA	SUPT16H →	+0.369	+0.547	<.001	<.001	3	6
BRCA	NOL10 →	+0.512	+0.567	<.001	<.001	3	6
GBM	ATAD2 →	+0.570	+1.004	<.001	<.001	3	6
BRCA	SF3B3 →	+0.251	+0.544	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,525 associations by consensus.

TERT vs PRIM2 — GBM

Explore this scatter interactively →