TERF2IP

Across TCGA patient cohorts, TERF2IP mutation is significantly associated with the RNA expression of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TERF2IP-associated genes across cancer lineages are RN7SKP223, RNU6-776P, and MIR5787. Each is linked with TERF2IP in more than 1 cancer types. Because this analysis shows association rather than direction, both TERF2IP-to-partner and partner-to-TERF2IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP223 grouped by TERF2IP-low versus TERF2IP-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TERF2IP→partner) and Y-score (partner→TERF2IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SKP223 →	+0.613	+7.741	<.001	.009	3	2
BRCA	RNU6-776P →	+0.282	+8.471	<.001	.005	3	2
CESC	MIR5787 →	+0.610	+5.969	<.001	.002	3	2
UCEC	RNA5SP419 →	+0.752	+3.077	.002	.005	3	2
COAD	RNU6-364P →	+0.418	+7.741	<.001	.009	3	1
COAD	RNU6-929P →	+0.368	+7.741	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

RN7SKP223 by TERF2IP expression — COAD

Explore this box plot interactively →