TERF2IP

Across TCGA pan-cancer cohorts, TERF2IP RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of TERF2IP’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TERF2IP RNA is repressed in tumor relative to normal tissue. In most cancer types TERF2IP is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LUSC are the cancer types where TERF2IP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TERF2IP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.430	<.001	10	view →
KICH	Male	All	−0.846	<.001	9	view →
LUSC	Male	II,III,IV	−0.606	<.001	9	view →
LUAD	All	II,III,IV	−0.282	<.001	9	view →
HNSC	All	III,IV	+0.367	.003	8	view →
UCEC	All	All	−1.102	<.001	6	view →
KIRP	All	II,III,IV	+0.400	.012	4	view →
BRCA	Female	II,III,IV	−0.301	<.001	4	view →
CHOL	Male	All	+1.421	<.001	3	view →
STAD	Male	II,III,IV	+0.466	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

TERF2IP–THCA

Open the THCA breakdown →