TERB1

Across TCGA cell cohorts, TERB1 mutation is significantly associated with the mutation status of many other genes, with 3,184 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TERB1-associated genes across cancer lineages are SOX2, SPEM2, and SLIT1. Each is linked with TERB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TERB1-to-partner and partner-to-TERB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SOX2 grouped by TERB1-low versus TERB1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TERB1→partner) and Y-score (partner→TERB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SOX2 →	+5.502	+5.502	.003	.003	1	3
LUNG_SCLC	SPEM2 →	+5.502	+5.502	.003	.003	1	3
LUNG_SCLC	SLIT1 →	+4.502	+5.066	.007	.007	1	3
LARGE_INTESTINE	KCTD3 →	+2.632	+2.632	.003	.003	1	3
LARGE_INTESTINE	RASGEF1B →	+3.632	+2.874	.002	.002	1	3
SKIN	AKNA →	+4.239	+5.053	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,184 associations by consensus.

SOX2 by TERB1 expression — LUNG_SCLC

Explore this box plot interactively →