TEP1

Across TCGA cell cohorts, TEP1 mutation is significantly associated with the RNA expression of many other genes, with 945 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TEP1-associated genes across cancer lineages are FEM1A, MRGPRD, and SPATA5L1. Each is linked with TEP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TEP1-to-partner and partner-to-TEP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FEM1A grouped by TEP1-low versus TEP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEP1→partner) and Y-score (partner→TEP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FEM1A →	+0.550	+3.489	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	MRGPRD →	+0.130	+3.584	<.001	.009	3	3
BLOOD_Leukemia	SPATA5L1 →	+0.328	+3.489	.008	.001	3	3
SOFT_TISSUE	GRXCR1 →	+0.090	+5.977	<.001	.001	3	2
PANCREAS	OR11H12 →	+0.074	+4.237	<.001	.006	3	2
PANCREAS	TBX5 →	+0.046	+4.237	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 945 associations by consensus.

FEM1A by TEP1 expression — BLOOD_Leukemia

Explore this box plot interactively →