TENT5D

Across TCGA patient cohorts, TENT5D mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TENT5D-associated genes across cancer lineages are Cyclin-E2, EGFR_pY1068, and ACC1. Each is linked with TENT5D in more than 2 cancer types. Because this analysis shows association rather than direction, both TENT5D-to-partner and partner-to-TENT5D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by TENT5D-low versus TENT5D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TENT5D→partner) and Y-score (partner→TENT5D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.113	+1.179	.024	.041	3	3
UCEC	EGFR_pY1068 →	-0.248	-1.807	<.001	<.001	3	2
SKCM	ACC1 →	+0.289	+2.700	.037	.006	3	2
UCEC	PDCD4 →	-0.575	-2.502	<.001	.001	3	2
SKCM	Rab25 →	-0.227	-2.700	.045	.006	3	2
UCEC	Shc_pY317 →	-0.174	-1.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Cyclin-E2 by TENT5D expression — UCEC

Explore this box plot interactively →