TENT5C

Across TCGA pan-cancer cohorts, TENT5C mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TENT5C data layer compared with 29 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TENT5C mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TENT5C expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

CCRCC, UCEC, and PDAC are the cancer types where TENT5C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.452	0.768	.020	11	view →
UCEC	OS	Tertile	III,IV	0.332	0.807	.042	8	view →
PDAC	OS	Tertile	IV	0.836	0.455	.024	6	view →
LUAD	DFS	Median	All	0.940	0.619	.010	4	view →
LSCC	DFS	Tertile	All	0.852	0.333	.012	4	view →
HNSC	DFS	Tertile	IV	0.780	0.635	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TENT5C–CCRCC (DFS)

Open the CCRCC breakdown →