TENT5C

Across TCGA patient cohorts, TENT5C mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TENT5C-associated genes across cancer lineages are C-Raf, Cyclin-B1, and Caspase-7-cleavedD198. Each is linked with TENT5C in more than 2 cancer types. Because this analysis shows association rather than direction, both TENT5C-to-partner and partner-to-TENT5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by TENT5C-low versus TENT5C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TENT5C→partner) and Y-score (partner→TENT5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.149	+2.222	.003	.010	3	3
UCEC	Cyclin-B1 →	+0.696	+2.906	<.001	.001	3	3
SKCM	Caspase-7-cleavedD198 →	+0.590	+2.195	.041	.032	3	3
UCEC	eIF4E →	+0.163	+3.472	.028	.002	3	2
UCEC	eIF4G →	+0.322	+1.662	.003	.011	3	2
UCEC	JNK_pT183_Y185 →	-0.125	-1.678	.036	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

C-Raf by TENT5C expression — UCEC

Explore this box plot interactively →