TENT5C

Across TCGA cell cohorts, TENT5C mutation is significantly associated with the mutation status of many other genes, with 2,755 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TENT5C-associated genes across cancer lineages are BCL9, SLC12A4, and ZSWIM4. Each is linked with TENT5C in more than 2 cancer types. Because this analysis shows association rather than direction, both TENT5C-to-partner and partner-to-TENT5C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BCL9 grouped by TENT5C-low versus TENT5C-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TENT5C→partner) and Y-score (partner→TENT5C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	BCL9 →	+4.539	+5.193	<.001	<.001	1	3
UPPER_AERODIGESTIVE_TRACT	SLC12A4 →	+4.954	+4.392	.008	.008	1	3
UPPER_AERODIGESTIVE_TRACT	ZSWIM4 →	+4.954	+4.392	.008	.008	1	3
UPPER_AERODIGESTIVE_TRACT	SMG1 →	+2.954	+4.247	.006	.006	1	3
BLOOD_Leukemia	NID2 →	+2.572	+4.129	.009	.009	1	3
LARGE_INTESTINE	PPP1R13B →	+2.422	+4.050	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,755 associations by consensus.

BCL9 by TENT5C expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →