TENT4B

Across TCGA pan-cancer cohorts, TENT4B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TENT4B data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher TENT4B mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TENT4B expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

GBM, LUAD, and LSCC are the cancer types where TENT4B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Quartile	All	0.646	0.321	.003	13	view →
LUAD	DFS	Quartile	II,III,IV	1.000	0.621	.005	12	view →
LSCC	DFS	Tertile	III,IV	0.649	1.000	.018	9	view →
CCRCC	DFS	Quartile	II,III,IV	0.828	0.423	.004	8	view →
PDAC	OS	Tertile	IV	0.231	0.908	.010	3	view →
HNSC	DFS	Median	IV	0.889	0.407	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TENT4B–GBM (OS)

Open the GBM breakdown →