TENT4B

Across TCGA pan-cancer cohorts, TENT4B RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of TENT4B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TENT4B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TENT4B is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and COAD are the cancer types where TENT4B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TENT4B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.671	<.001	12	view →
THCA	Female	All	−0.582	<.001	9	view →
COAD	Male	II,III,IV	+0.534	<.001	4	view →
BRCA	All	II,III,IV	+0.331	.002	4	view →
CHOL	All	All	+0.642	.009	2	view →
KICH	All	All	−0.364	.021	2	view →
LIHC	All	All	+0.302	.001	2	view →
LUAD	Female	II,III,IV	−0.367	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

TENT4B–HNSC

Open the HNSC breakdown →