TENT4A

Across TCGA patient cohorts, TENT4A mutation is significantly associated with the RNA expression of many other genes, with 3,760 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TENT4A-associated genes across cancer lineages are CCSAP, TXN2, and R3HCC1. Each is linked with TENT4A in more than 2 cancer types. Because this analysis shows association rather than direction, both TENT4A-to-partner and partner-to-TENT4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCSAP grouped by TENT4A-low versus TENT4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TENT4A→partner) and Y-score (partner→TENT4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCSAP →	+0.422	+1.708	.002	.001	3	3
UCEC	TXN2 →	+0.303	+2.248	<.001	<.001	3	3
UCEC	R3HCC1 →	+0.345	+2.008	<.001	<.001	3	3
UCEC	IFNG →	+0.671	+2.194	<.001	<.001	3	3
UCEC	SLC35B1 →	+0.322	+1.490	<.001	<.001	3	3
UCEC	HAT1 →	+0.449	+1.807	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,760 associations by consensus.

CCSAP by TENT4A expression — UCEC

Explore this box plot interactively →