TENT4A

Across TCGA pan-cancer cohorts, TENT4A RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated TENT4A data layer compared with 7 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TENT4A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TENT4A expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

KIRP, HNSC, and ACC are the cancer types where TENT4A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	0.262	0.719	<.001	122	view →
HNSC	DFS	Median	IV	0.424	0.202	<.001	68	view →
ACC	OS	Quartile	All	0.418	0.812	.002	63	view →
COAD	DFS	Quartile	III,IV	0.286	0.708	.002	56	view →
MESO	OS	Median	All	0.450	0.624	.002	54	view →
UVM	DFS	Quartile	All	0.288	0.775	.002	49	view →
UCEC	DFS	Quartile	All	0.770	0.880	.005	28	view →
LUAD	DFS	Median	IV	0.514	0.847	.015	24	view →
SKCM	OS	Median	III,IV	0.850	0.744	.009	21	view →
LIHC	DFS	Tertile	All	0.453	0.615	<.001	19	view →
BRCA	DFS	Median	IV	0.345	0.673	.023	15	view →
THYM	OS	Median	All	1.000	0.925	.019	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

TENT4A–KIRP (DFS)

Open the KIRP breakdown →