TENT4A

Across TCGA cell cohorts, TENT4A mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible TENT4A-associated genes across cancer lineages are MUC7, OR2T4, and RBMY1D. Each is linked with TENT4A in more than 1 cancer types. Because this analysis shows association rather than direction, both TENT4A-to-partner and partner-to-TENT4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MUC7 grouped by TENT4A-low versus TENT4A-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TENT4A→partner) and Y-score (partner→TENT4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MUC7 →	+0.198	+5.169	<.001	<.001	3	1
LUNG_SCLC	OR2T4 →	+0.062	+4.643	<.001	.004	3	1
LUNG_SCLC	RBMY1D →	+0.281	+4.817	<.001	.001	3	1
LARGE_INTESTINE	MYOZ1 →	+0.320	+3.459	.001	.008	3	1
LARGE_INTESTINE	FAM205A →	+0.022	+4.614	<.001	.002	3	1
LARGE_INTESTINE	SCT →	+0.168	+3.510	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MUC7 by TENT4A expression — LUNG_SCLC

Explore this box plot interactively →