TENM4

Across TCGA pan-cancer cohorts, TENM4 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated TENM4 data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher TENM4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TENM4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.

THYM, UCEC, and CESC are the cancer types where TENM4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	OS	Median	All	0.926	0.638	.005	34	view →
CESC	OS	Median	IV	0.091	0.593	<.001	30	view →
SKCM	OS	Median	All	0.757	0.886	.001	8	view →
BRCA	DFS	Median	All	0.162	0.528	.004	6	view →
SARC	DFS	Median	All	0.121	0.591	.042	3	view →
READ	DFS	Median	All	0.174	0.602	.045	3	view →
LUSC	OS	Median	III,IV	0.279	0.578	.040	3	view →
COAD	OS	Median	III,IV	0.921	0.480	.031	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

TENM4–THYM (OS)

Open the THYM breakdown →