TENM4

Across TCGA pan-cancer cohorts, TENM4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TENM4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TENM4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TENM4 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

HNSC, LUAD, and THCA are the cancer types where TENM4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TENM4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.259	<.001	11	view →
LUAD	Male	All	+1.286	<.001	9	view →
THCA	Male	All	−1.172	<.001	8	view →
BLCA	All	All	+0.942	.002	8	view →
COAD	All	All	+0.419	<.001	8	view →
LUSC	Female	All	+2.477	<.001	7	view →
BRCA	Female	II,III,IV	+0.363	.002	6	view →
UCEC	All	All	−0.814	.034	4	view →
KIRC	All	II,III,IV	−0.357	.020	4	view →
CHOL	Female	All	+0.630	.002	2	view →
STAD	All	IV	+0.500	.024	1	view →
LIHC	All	All	+0.064	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TENM4–HNSC

Open the HNSC breakdown →