TENM4

Across TCGA pan-cancer cohorts, TENM4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TENM4 data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TENM4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TENM4 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

PDAC, GBM, and HNSC are the cancer types where TENM4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.658	0.844	.016	8	view →
GBM	DFS	Quartile	All	0.203	0.535	.008	5	view →
HNSC	OS	Median	IV	0.619	0.934	.022	3	view →
LUAD	OS	Median	II,III,IV	0.820	0.527	.016	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TENM4–PDAC (DFS)

Open the PDAC breakdown →