TENM4

Across TCGA patient cohorts, TENM4 mutation is significantly associated with the total protein of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TENM4-associated genes across cancer lineages are Caveolin-1, INPP4B, and Caspase-7-cleavedD198. Each is linked with TENM4 in more than 5 cancer types. Because this analysis shows association rather than direction, both TENM4-to-partner and partner-to-TENM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caveolin-1 grouped by TENM4-low versus TENM4-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TENM4→partner) and Y-score (partner→TENM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caveolin-1 →	-0.675	-1.807	.003	.003	3	6
COAD	INPP4B →	-0.281	-1.515	.009	.007	3	5
COAD	Caspase-7-cleavedD198 →	+0.990	+2.067	<.001	<.001	3	5
COAD	FASN →	+0.419	+1.736	<.001	.005	3	4
COAD	4E-BP1 →	+0.241	+2.067	<.001	<.001	3	4
STAD	C-Raf →	+0.164	+2.000	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

Caveolin-1 by TENM4 expression — STAD

Explore this box plot interactively →