TENM4

Across TCGA cell cohorts, TENM4 mutation is significantly associated with the RNA expression of many other genes, with 1,094 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TENM4-associated genes across cancer lineages are LYG1, INTS8, and ACTL7A. Each is linked with TENM4 in more than 3 cancer types. Because this analysis shows association rather than direction, both TENM4-to-partner and partner-to-TENM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYG1 grouped by TENM4-low versus TENM4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TENM4→partner) and Y-score (partner→TENM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LYG1 →	+0.930	+2.043	<.001	.001	2	4
LARGE_INTESTINE	INTS8 →	+0.440	+1.628	.008	.007	3	3
BONE	ACTL7A →	+0.098	+3.836	.001	.004	3	2
PANCREAS	ETV3L →	+0.042	+2.841	<.001	.007	3	2
BONE	RTP2 →	+0.104	+3.672	.001	.004	3	2
SOFT_TISSUE	KRT6C →	+0.005	+2.930	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,094 associations by consensus.

LYG1 by TENM4 expression — LARGE_INTESTINE

Explore this box plot interactively →