TENM3-AS1

Across TCGA patient cohorts, TENM3-AS1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TENM3-AS1-associated genes across cancer lineages are c-Met_pY1235, A-Raf_pS299, and ERK2. Each is linked with TENM3-AS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TENM3-AS1-to-partner and partner-to-TENM3-AS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by TENM3-AS1-low versus TENM3-AS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TENM3-AS1→partner) and Y-score (partner→TENM3-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.082	+2.115	.011	.019	3	2
UCEC	A-Raf_pS299 →	-0.170	-3.459	.001	.005	3	1
UCEC	ERK2 →	+0.170	+2.115	.043	.019	3	1
UCEC	Fibronectin →	-0.291	-2.115	.043	.019	3	1
UCEC	HER3_pY1289 →	+0.085	+1.611	.023	.043	3	1
UCEC	Ku80 →	+0.276	+1.598	.007	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

c-Met_pY1235 by TENM3-AS1 expression — UCEC

Explore this box plot interactively →