TENM3-AS1

Across TCGA pan-cancer cohorts, TENM3-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TENM3-AS1 data layer compared with 2 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher TENM3-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TENM3-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and PAAD show a favorable association.

UVM, MESO, and KICH are the cancer types where TENM3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.519	0.896	<.001	87	view →
MESO	DFS	Median	All	0.270	0.450	.001	76	view →
KICH	OS	Median	III,IV	0.759	1.000	.005	71	view →
LUSC	OS	Tertile	III,IV	0.367	0.704	.001	67	view →
BLCA	DFS	Quartile	All	0.432	0.582	.005	55	view →
SARC	DFS	Median	All	0.418	0.602	<.001	36	view →
SKCM	DFS	Median	IV	0.650	0.187	.001	27	view →
LGG	DFS	Quartile	All	0.343	0.549	.004	25	view →
PAAD	OS	Tertile	II,III,IV	0.747	0.385	<.001	20	view →
LIHC	OS	Tertile	All	0.688	0.803	.020	18	view →
ESCA	OS	Quartile	All	0.781	0.503	.011	18	view →
CHOL	OS	Median	II,III,IV	0.823	0.294	.007	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TENM3-AS1–UVM (DFS)

Open the UVM breakdown →