TENM2

Across TCGA patient cohorts, TENM2 mutation is significantly associated with the RNA expression of many other genes, with 10,152 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TENM2-associated genes across cancer lineages are RTN3, THUMPD3, and OR10H5. Each is linked with TENM2 in more than 4 cancer types. Because this analysis shows association rather than direction, both TENM2-to-partner and partner-to-TENM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RTN3 grouped by TENM2-low versus TENM2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TENM2→partner) and Y-score (partner→TENM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RTN3 →	+0.578	+2.835	.001	.001	3	5
UCEC	THUMPD3 →	+0.438	+2.050	<.001	<.001	3	5
BLCA	OR10H5 →	+0.131	+1.715	.004	.004	3	5
BLCA	LRRC8B →	+0.611	+3.413	<.001	<.001	3	5
LUAD	GBGT1 →	-0.505	-2.662	<.001	<.001	3	5
LUAD	CD1C →	-0.901	-2.976	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,152 associations by consensus.

RTN3 by TENM2 expression — BLCA

Explore this box plot interactively →