TENM2

Across TCGA pan-cancer cohorts, TENM2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TENM2 data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher TENM2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TENM2 expression acts as an unfavorable survival marker, although some lineages such as PAAD and SCLC show a favorable association.

MESO, SKCM, and HNSC are the cancer types where TENM2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.413	0.665	<.001	121	view →
SKCM	OS	Median	All	0.715	0.838	<.001	74	view →
HNSC	OS	Tertile	All	0.698	0.824	<.001	62	view →
BLCA	OS	Median	All	0.340	0.508	.001	60	view →
LUAD	DFS	Tertile	IV	0.343	0.888	<.001	58	view →
ACC	DFS	Tertile	All	0.176	0.638	<.001	43	view →
KIRP	DFS	Quartile	All	0.834	0.956	.006	34	view →
PAAD	OS	Median	All	0.708	0.464	<.001	29	view →
THCA	OS	Quartile	All	0.977	1.000	.003	23	view →
SCLC	OS	Quartile	All	0.939	0.486	.024	15	view →
UCEC	OS	Tertile	All	0.886	0.941	.009	10	view →
GBM	OS	Quartile	All	0.349	0.539	.021	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TENM2–MESO (OS)

Open the MESO breakdown →