TENM2

Across TCGA patient cohorts, TENM2 mutation is significantly associated with the total protein of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TENM2-associated genes across cancer lineages are Caspase-8, 4E-BP1, and C-Raf. Each is linked with TENM2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TENM2-to-partner and partner-to-TENM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by TENM2-low versus TENM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TENM2→partner) and Y-score (partner→TENM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.221	-3.143	<.001	<.001	3	4
UCEC	4E-BP1 →	+0.309	+1.523	<.001	<.001	3	4
UCEC	C-Raf →	+0.122	+1.192	<.001	.005	3	4
SKCM	GAPDH →	+0.366	+1.415	.010	.006	3	4
LUAD	mTOR →	-0.149	-1.362	.045	.035	3	3
LUAD	AMPK_pT172 →	-0.321	-2.000	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

Caspase-8 by TENM2 expression — UCEC

Explore this box plot interactively →