TENM2

Across TCGA cell cohorts, TENM2 mutation is significantly associated with the RNA expression of many other genes, with 2,628 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TENM2-associated genes across cancer lineages are HELLS, PTER, and GGTLC3. Each is linked with TENM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TENM2-to-partner and partner-to-TENM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HELLS grouped by TENM2-low versus TENM2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TENM2→partner) and Y-score (partner→TENM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HELLS →	+0.603	+3.321	.008	.005	3	3
CNS	PTER →	+1.281	+2.584	.001	.006	3	3
STOMACH	GGTLC3 →	+0.119	+3.058	.001	.001	3	3
LARGE_INTESTINE	RPL3 →	+0.441	+2.767	.001	<.001	3	3
BLOOD_Leukemia	NEIL3 →	+1.124	+3.228	<.001	.004	3	3
BLOOD_Leukemia	GOT1 →	+0.599	+2.584	.008	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,628 associations by consensus.

HELLS by TENM2 expression — CNS

Explore this box plot interactively →