TELO2

Across TCGA patient cohorts, TELO2 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TELO2-associated genes across cancer lineages are ATM, EGFR_pY1068, and FOXO3a_pS318_S321. Each is linked with TELO2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TELO2-to-partner and partner-to-TELO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TELO2-low versus TELO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TELO2→partner) and Y-score (partner→TELO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.559	-2.247	<.001	.001	3	3
SKCM	EGFR_pY1068 →	-0.156	-2.982	.025	.034	3	2
UCEC	FOXO3a_pS318_S321 →	-0.136	-2.247	.003	.001	3	2
UCEC	JNK_pT183_Y185 →	-0.193	-2.502	.001	.001	3	2
UCEC	mTOR_pS2448 →	-0.171	-2.787	.001	.003	3	2
UCEC	Notch1 →	+0.147	+1.820	.004	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

ATM by TELO2 expression — UCEC

Explore this box plot interactively →