TEKT3

Across TCGA patient cohorts, TEKT3 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEKT3-associated genes across cancer lineages are PKC-b-II_pS660, 4E-BP1, and 4E-BP1_pT70. Each is linked with TEKT3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TEKT3-to-partner and partner-to-TEKT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by TEKT3-low versus TEKT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEKT3→partner) and Y-score (partner→TEKT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-b-II_pS660 →	-0.298	-1.847	.003	.008	3	3
UCEC	4E-BP1 →	+0.289	+2.489	.003	.010	3	3
COAD	4E-BP1_pT70 →	+0.166	+3.008	.007	.019	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.500	+2.469	.007	.010	3	2
UCEC	INPP4B →	-0.272	-1.700	.022	.042	3	2
UCEC	PKC-delta_pS664 →	-0.133	-2.807	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

PKC-b-II_pS660 by TEKT3 expression — UCEC

Explore this box plot interactively →