TEKT3

Across TCGA pan-cancer cohorts, TEKT3 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated TEKT3 data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TEKT3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TEKT3 expression acts as an unfavorable survival marker, although some lineages such as UVM and UCS show a favorable association.

UVM, ACC, and THCA are the cancer types where TEKT3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.809	0.427	<.001	95	view →
ACC	DFS	Quartile	All	0.183	0.555	.001	68	view →
THCA	DFS	Quartile	II,III,IV	0.826	0.949	<.001	57	view →
LGG	DFS	Median	All	0.670	0.795	<.001	40	view →
UCS	OS	Median	II,III,IV	0.626	0.359	.020	36	view →
PAAD	DFS	Median	All	0.368	0.206	.004	27	view →
UCEC	OS	Tertile	All	0.959	0.894	.004	26	view →
HNSC	OS	Tertile	III,IV	0.499	0.310	.009	24	view →
BRCA	DFS	Quartile	IV	0.904	0.286	.007	18	view →
LAML	DFS	Quartile	All	0.548	0.284	.013	14	view →
LUAD	DFS	Median	All	0.855	0.767	.012	13	view →
GBM	DFS	Median	All	0.192	0.376	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

TEKT3–UVM (OS)

Open the UVM breakdown →