TEK

Across TCGA patient cohorts, TEK mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEK-associated genes across cancer lineages are TFRC, Cyclin-B1, and EGFR. Each is linked with TEK in more than 2 cancer types. Because this analysis shows association rather than direction, both TEK-to-partner and partner-to-TEK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by TEK-low versus TEK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEK→partner) and Y-score (partner→TEK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.412	+2.807	.010	.002	3	3
UCEC	Cyclin-B1 →	+0.545	+1.906	.001	.014	3	3
UCEC	EGFR →	-0.163	-2.781	<.001	.003	3	2
COAD	Caspase-7-cleavedD198 →	+1.431	+3.186	<.001	.009	3	2
UCEC	c-Met →	-0.192	-1.854	.034	.002	3	2
COAD	c-Myc →	-0.266	-3.446	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

TFRC by TEK expression — UCEC

Explore this box plot interactively →