TEK

Across TCGA cell cohorts, TEK mutation is significantly associated with the RNA expression of many other genes, with 676 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TEK-associated genes across cancer lineages are MAGEB4, SEMA3G, and ULBP3. Each is linked with TEK in more than 1 cancer types. Because this analysis shows association rather than direction, both TEK-to-partner and partner-to-TEK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by TEK-low versus TEK-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEK→partner) and Y-score (partner→TEK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MAGEB4 →	+0.010	+5.022	<.001	.002	3	2
LARGE_INTESTINE	SEMA3G →	+0.664	+2.628	.005	.002	3	2
LARGE_INTESTINE	ULBP3 →	+0.904	+3.523	<.001	<.001	3	2
LARGE_INTESTINE	RAP1GDS1 →	+0.565	+2.628	.001	.002	3	2
LARGE_INTESTINE	PGD →	+0.694	+3.459	.003	<.001	3	2
LARGE_INTESTINE	LZIC →	+0.555	+2.628	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 676 associations by consensus.

MAGEB4 by TEK expression — SKIN

Explore this box plot interactively →