TEF

Across TCGA patient cohorts, TEF mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TEF-associated genes across cancer lineages are p62 Lck ligand, p70-S6K, and Rab11. Each is linked with TEF in more than 1 cancer types. Because this analysis shows association rather than direction, both TEF-to-partner and partner-to-TEF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by TEF-low versus TEF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEF→partner) and Y-score (partner→TEF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.451	+3.009	.011	.019	3	1
UCEC	p70-S6K →	+0.232	+3.196	.028	.010	3	1
UCEC	Rab11 →	-0.165	-3.169	.038	.020	3	1
UCEC	Annexin_VII →	-0.151	-3.169	.048	.020	3	1
UCEC	STAT3_pY705 →	-0.471	-3.169	.001	.020	3	1
UCEC	TFRC →	+0.863	+3.169	.003	.020	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

p62 Lck ligand by TEF expression — UCEC

Explore this box plot interactively →