TEF

Across TCGA cell cohorts, TEF mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TEF-associated genes across cancer lineages are SPRR1A, CST11, and RIPPLY1. Each is linked with TEF in more than 1 cancer types. Because this analysis shows association rather than direction, both TEF-to-partner and partner-to-TEF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPRR1A grouped by TEF-low versus TEF-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEF→partner) and Y-score (partner→TEF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPRR1A →	+0.287	+5.201	<.001	.006	3	1
BLOOD_Lymphoma	CST11 →	+1.225	+4.714	<.001	.002	3	1
BLOOD_Lymphoma	RIPPLY1 →	+0.024	+4.191	.009	.007	3	1
BLOOD_Lymphoma	SLC38A8 →	+0.104	+4.191	<.001	.007	3	1
BLOOD_Lymphoma	OR52B2 →	+0.031	+4.714	<.001	.002	3	1
LARGE_INTESTINE	BTNL2 →	+0.081	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

SPRR1A by TEF expression — BLOOD_Leukemia

Explore this box plot interactively →