TECTA

Across TCGA cell cohorts, TECTA mutation is significantly associated with the mutation status of many other genes, with 5,262 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TECTA-associated genes across cancer lineages are HDAC4, TAOK2, and NBEA. Each is linked with TECTA in more than 6 cancer types. Because this analysis shows association rather than direction, both TECTA-to-partner and partner-to-TECTA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HDAC4 grouped by TECTA-low versus TECTA-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TECTA→partner) and Y-score (partner→TECTA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	HDAC4 →	+4.614	+3.672	.002	.002	1	7
BLOOD_Leukemia	TAOK2 →	+3.063	+2.525	.001	.001	1	7
KIDNEY	NBEA →	+5.000	+5.000	.006	.006	1	6
CNS	KIAA1549 →	+2.785	+2.785	.001	.001	1	6
SKIN	ZNF71 →	+3.959	+2.245	.005	.005	1	6
BREAST	TBC1D8 →	+3.558	+3.095	.008	.008	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,262 associations by consensus.

HDAC4 by TECTA expression — PANCREAS

Explore this box plot interactively →