TECR

Across TCGA patient cohorts, TECR mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TECR-associated genes across cancer lineages are SF2, EGFR_pY1068, and JNK2. Each is linked with TECR in more than 1 cancer types. Because this analysis shows association rather than direction, both TECR-to-partner and partner-to-TECR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SF2 grouped by TECR-low versus TECR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TECR→partner) and Y-score (partner→TECR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SF2 →	-0.131	-3.159	.010	.019	3	2
UCEC	EGFR_pY1068 →	-0.337	-3.700	.003	.001	3	1
UCEC	JNK2 →	+0.208	+2.817	.025	.036	3	1
UCEC	Ku80 →	+0.313	+2.598	.004	.006	3	1
UCEC	MEK1 →	+0.517	+3.700	.002	.001	3	1
UCEC	N-Ras →	-0.117	-2.571	.034	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

SF2 by TECR expression — UCEC

Explore this box plot interactively →