TECR

Across TCGA cell cohorts, TECR mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TECR-associated genes across cancer lineages are H1-8, OR8K3, and GML. Each is linked with TECR in more than 1 cancer types. Because this analysis shows association rather than direction, both TECR-to-partner and partner-to-TECR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H1-8 grouped by TECR-low versus TECR-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TECR→partner) and Y-score (partner→TECR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	H1-8 →	+0.030	+6.357	<.001	<.001	3	1
CNS	OR8K3 →	+0.006	+5.754	.002	.002	3	1
BLOOD_Leukemia	GML →	+0.080	+4.152	<.001	.009	3	1
BLOOD_Leukemia	GFRA4 →	+0.295	+4.409	.001	.005	3	1
BLOOD_Leukemia	TSHB →	+0.120	+4.276	.005	.007	3	1
BLOOD_Leukemia	AWAT2 →	+0.010	+4.705	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

H1-8 by TECR expression — CNS

Explore this box plot interactively →