TEAD3

Across TCGA cell cohorts, TEAD3 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TEAD3-associated genes across cancer lineages are CLDN17, SSMEM1, and LRRC3C. Each is linked with TEAD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TEAD3-to-partner and partner-to-TEAD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLDN17 grouped by TEAD3-low versus TEAD3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TEAD3→partner) and Y-score (partner→TEAD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CLDN17 →	+0.052	+3.930	.001	.003	3	1
LARGE_INTESTINE	SSMEM1 →	+0.030	+3.707	<.001	.009	3	1
LARGE_INTESTINE	LRRC3C →	+0.365	+3.777	<.001	.007	3	1
LARGE_INTESTINE	OR5V1 →	+0.008	+4.437	<.001	.004	3	1
LARGE_INTESTINE	TBC1D3 →	+0.075	+4.688	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

CLDN17 by TEAD3 expression — LARGE_INTESTINE

Explore this box plot interactively →