TDRKH

Across TCGA pan-cancer cohorts, TDRKH mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TDRKH data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TDRKH mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TDRKH expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

LUAD, GBM, and HNSC are the cancer types where TDRKH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.926	0.690	.004	31	view →
GBM	DFS	Tertile	All	0.851	0.583	.002	14	view →
HNSC	OS	Quartile	All	0.140	1.000	.017	14	view →
OV	DFS	Tertile	All	0.557	1.000	.031	8	view →
CCRCC	DFS	Quartile	III,IV	0.233	0.830	.038	3	view →
LSCC	DFS	Tertile	All	1.000	0.848	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TDRKH–LUAD (OS)

Open the LUAD breakdown →