TDRKH

Across TCGA patient cohorts, TDRKH mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TDRKH-associated genes across cancer lineages are A-Raf_pS299, PKC-delta_pS664, and PKC-a. Each is linked with TDRKH in more than 1 cancer types. Because this analysis shows association rather than direction, both TDRKH-to-partner and partner-to-TDRKH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by TDRKH-low versus TDRKH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDRKH→partner) and Y-score (partner→TDRKH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.122	-2.459	.016	.019	3	2
UCEC	PKC-delta_pS664 →	-0.114	-2.459	.025	.018	3	2
SKCM	PKC-a →	-0.445	-2.000	.014	.031	3	2
COAD	Caspase-7-cleavedD198 →	+1.193	+2.815	.005	.036	3	2
UCEC	eEF2 →	+0.449	+1.700	.003	.044	3	1
UCEC	EGFR_pY1068 →	-0.366	-4.000	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

A-Raf_pS299 by TDRKH expression — UCEC

Explore this box plot interactively →