TDRD5

Across TCGA cell cohorts, TDRD5 mutation is significantly associated with the RNA expression of many other genes, with 381 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TDRD5-associated genes across cancer lineages are TOPAZ1, TTI2, and ALDH1B1. Each is linked with TDRD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TDRD5-to-partner and partner-to-TDRD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TOPAZ1 grouped by TDRD5-low versus TDRD5-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDRD5→partner) and Y-score (partner→TDRD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TOPAZ1 →	+0.031	+4.523	<.001	.003	3	2
LARGE_INTESTINE	TTI2 →	+0.637	+3.137	.001	.007	3	2
LARGE_INTESTINE	ALDH1B1 →	+1.010	+3.169	.001	.009	3	2
LARGE_INTESTINE	REG1B →	+1.776	+2.196	<.001	.004	3	2
LARGE_INTESTINE	GET3 →	+0.484	+3.502	.001	.001	3	2
OESOPHAGUS	PROP1 →	+0.030	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 381 associations by consensus.

TOPAZ1 by TDRD5 expression — LUNG_SCLC

Explore this box plot interactively →