TDP2

Across TCGA pan-cancer cohorts, TDP2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TDP2 data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TDP2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TDP2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LUAD, LSCC, and PDAC are the cancer types where TDP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.936	0.982	.011	12	view →
LSCC	DFS	Quartile	All	0.847	0.528	.020	11	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	9	view →
HNSC	OS	Tertile	IV	0.847	0.608	.025	6	view →
UCEC	DFS	Median	II,III,IV	0.534	0.867	.040	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TDP2–LUAD (OS)

Open the LUAD breakdown →