TDP2

Across TCGA pan-cancer cohorts, TDP2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TDP2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TDP2 RNA is repressed in tumor relative to normal tissue. In most cancer types TDP2 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, HNSC, and LIHC are the cancer types where TDP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TDP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.345	<.001	12	view →
HNSC	Male	IV	+1.057	<.001	11	view →
LIHC	Male	II,III,IV	+1.204	<.001	9	view →
KICH	Female	II,III,IV	−1.875	<.001	8	view →
KIRP	Male	All	−0.729	<.001	8	view →
READ	All	All	−1.662	<.001	7	view →
BLCA	Female	IV	+0.533	.020	6	view →
BRCA	All	II,III,IV	+0.323	<.001	6	view →
CHOL	All	All	+1.314	<.001	3	view →
KIRC	All	II,III,IV	+0.289	.017	3	view →
LUAD	All	All	+0.243	.008	2	view →
BLCA	Male	IV	−0.377	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TDP2–COAD

Open the COAD breakdown →