TDP2

Across TCGA patient cohorts, TDP2 protein abundance is significantly associated with the RNA expression of many other genes, with 14,748 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TDP2-associated genes across cancer lineages are KIFC1, ZNF724, and E2F2. Each is linked with TDP2 in more than 5 cancer types. Because this analysis shows association rather than direction, both TDP2-to-partner and partner-to-TDP2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TDP2 versus KIFC1 in OV, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TDP2→partner) and Y-score (partner→TDP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	KIFC1 →	+1.401	+0.547	<.001	<.001	3	6
UCEC	ZNF724 →	+0.732	+0.273	<.001	<.001	3	5
BRCA	E2F2 →	+0.928	+0.364	<.001	<.001	3	5
BRCA	GMNN →	+0.941	+0.333	<.001	<.001	3	5
OV	ESPL1 →	+0.952	+0.422	.002	.002	3	5
BRCA	BUB1B →	+1.176	+0.383	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,748 associations by consensus.

TDP2 vs KIFC1 — OV

Explore this scatter interactively →